Does your center want to participate? Join us! Please see the infographic below on which steps you have to take. Click here to view the infographic intended for Dutch hospitals only.
Design and rationale of this registry
A pneumonia of unknown cause occurring in Wuhan, China was reported on 31 December 2019 to the WHO Country Office in China. A new coronavirus virus called SARS-CoV-2 turned out to be the cause of the outbreak. This virus can cause the disease COVID-19. Due to rapid spreading of the virus, the WHO declared the outbreak a Public Health Emergency of International Concern on 30 January 2020. Since 11 March 2020, COVID-19 is considered to be a pandemic.
From emerging literature on the clinical disease manifestation of COVID-19, fever and respiratory symptoms seem most common. However, a significant number of patients develops cardiovascular complications. Furthermore, patients with pre-existent cardiovascular comorbidities seem to have an increased chance of developing serious complications of COVID-19. Insufficient evidence is currently available to guide monitoring of cardiovascular complications and treatment decisions in COVID-19 patients with a history of cardiovascular disease.
CAPACITY is a registry of patients with COVID-19 including cardiovascular risk and complications. It is an extension of the Case Record Form (CRF) that was released by the ISARIC (International Severe Acute Respiratory and Emerging Infection Consortium) and WHO (World Health Organisation) in response to the emerging outbreak of COVID-19.
The aim of CAPACITY is to collect data regarding the cardiovascular history, diagnostic information and occurrence of cardiovascular complications in COVID-19 patients. By collecting this information in a standardized manner, CAPACITY can aid in providing more insight in (1) the establishment and incidence of cardiovascular complications in patients with COVID-19, and (2) the vulnerability and clinical course of COVID-19 in patients with an underlying cardiovascular disease.
Study documents (global)
Clicking on the document icon will instantly start the download.
Study protocol (English only):
REDCap codebook (English only):
Data Quality Checks (English only):
Standard Operating Procedure REDCap Uploading Images (English only):
REDCap account request formulier (English only):
Standard Operating Procedure (SOP) Study ID’s (English or Dutch):
Operating Procedure sharing data with ISARIC (English only)
Template Patient Information Form (PIF) (English, Dutch, Portuguese or Italian):
Template Opt-Out for patients (English, Dutch, Portuguese or Italian):
CAPACITY one pager (English only):
Please contact us for the Data Transfer Agreement (DTA).
Study documents UK specific
UK Study Protocol
UK Data Dictionary
UK Capacity Frequently Asked Questions
Admiraal de Ruyter Hospital
Albert Schweitzer Hospital
Amsterdam University Medical Center
Antwerp University Hospital
AZ Maria Middelares
Barts Health NHS Trust
CHU UCL Namur – Site Godinne
Purmerend – Hoorn
Erasmus University Medical Center
Groene Hart Hospital
Haaglanden Medical Center
Hospital do Espirito Santo
Hospital Group Twente
Hospital Prof. Doutor Fernando Fonesca
I.M. Sechenov First Moscow State Medical University
Incliva Research Institute, University of Valencia
Jeroen Bosch Hospital
King Fahd Hospital of the University
Leeds Teaching Hospitals NHS Trust
Leeuwarden Medical Center
Leiden University Medical Center
Maastricht University Medical Center
Meander Medical Center
Medisch Spectrum Twente
Northumbria Healthcare NHS Foundation Trust
One Day Surgery Hospital
Rode Kruis Hospital
Royal Devon and Exeter NHS Foundation Trust
Salford Royal NHS Foundation Trust
San Luigi Gonzaga University Hospital
Saxenburgh Medical Center
Southern Health and Social Care Trust
SSR Val Rosay
St. Antonius Hospital
Tehran Heart Center
The Newcastle upon Tyne Hospitals NHS Foundation Trust
University College London Hospitals NHS Foundation Trust
University Hospital Brussels
University Hospital Complex of Granada
University Hospital of Geneva
University Hospitals Bristol NHS Foundation Trust
University Hospitals of Leicester NHS Trust
University Medical Center Utrecht
van Weel-Bethseda Hospital
Zaans Medical Center
Zuyderland Medical Center
Approved research projects and Data access
Together we are investigating the role cardiovascular disease in the COVID-19 pandemic. We sincerely invite our international colleagues and researchers to apply for data access or to join efforts that are already ongoing. The following six research questions have formulated by the Data Access Committee and are being assessed:
What is the incidence and pattern of cardiovascular complications in patients with COVID-19?
Does the clinical presentation of COVID-19 differ between patients with and without a history of cardiovascular disease?
What is the extent of cardiac damage in patients with COVID-19?
Do patients with COVID-19 and cardiovascular risk factors or underlying cardiovascular disease have a worse disease course? If this is the case, which cardiovascular risk factors and types of cardiovascular diseases are especially associated with a poor outcome?
Does the use of medication that influence ACE-2 expression worsen the course of COVID-19 (ACEi, ARBs, NSAIDs and thiazolidinediones)?
What is the effect of therapy for COVID-19 on patients with cardiac complications or underlying cardiovascular disease? E.g. chloroquine and effect on QT-interval.
The following requests for data access have been approved:
Oral anticoagulation and COVID-19 outcome – Disease modifiers
Sex differences in COVID-19
Effect of diabetes on COVID-19 cardiovascular complications
Acute cardiac injury and ACS in COVID-19
Arrhythmias and conduction disorders in COVID-19
Non-invasive 12-lead ECG analysis in patients with COVID-19
Disease-specific ECG features in patients with COVID-19
This research is observational, data acquired during routine clinical care will be registered. Data of the admission will be collected with standardized Data Collection Instruments in REDCap. In addition to the ISARIC-WHO CRF, the CAPACITY REDCap project has multiple additional Data Collection Instruments, including: cardiac history and cardiovascular risk factors, cardiac biomarkers, ECG, echocardiography, cardiac MRI, invasive cardiac procedures, cardiac complications during admission and cardiac outcome after 7 and 30 days.