Information & documents for professionals

Does your center want to participate? Join us! Please see the infographic below on which steps you have to take. Click here to view the infographic intended for Dutch hospitals only.

A pneumonia of unknown cause occurring in Wuhan, China was reported on 31 December 2019 to the WHO Country Office in China. A new coronavirus virus called SARS-CoV-2 turned out to be the cause of the outbreak. This virus can cause the disease COVID-19. Due to rapid spreading of the virus, the WHO declared the outbreak a Public Health Emergency of International Concern on 30 January 2020.  Since 11 March 2020, COVID-19 is considered to be a pandemic.

From emerging literature on the clinical disease manifestation of COVID-19, fever and respiratory symptoms seem most common. However, a significant number of patients develops cardiovascular complications. Furthermore, patients with pre-existent cardiovascular comorbidities seem to have an increased chance of developing serious complications of COVID-19. Insufficient evidence is currently available to guide monitoring of cardiovascular complications and treatment decisions in COVID-19 patients with a history of cardiovascular disease.

CAPACITY is a registry of patients with COVID-19 including cardiovascular risk and complications. It is an extension of the Case Record Form (CRF) that was released by the ISARIC (International Severe Acute Respiratory and Emerging Infection Consortium) and WHO (World Health Organisation) in response to the emerging outbreak of COVID-19. 

The aim of CAPACITY is to collect data regarding the cardiovascular history, diagnostic information and occurrence of cardiovascular complications in COVID-19 patients. By collecting this information in a standardized manner, CAPACITY can aid in providing more insight in (1) the establishment and incidence of cardiovascular complications in patients with COVID-19, and (2) the vulnerability and clinical course of COVID-19 in patients with an underlying cardiovascular disease. 

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Study Protocol
Study protocol (English only):

REDCap codebook (English only):


Data Quality Checks (English only):
Standard Operating Procedure REDCap Uploading Images (English only):
REDCap account request formulier (English only):
Operating Procedures
Standard Operating Procedure (SOP) Study ID’s (English or Dutch):


Operating Procedure sharing data with ISARIC (English only)
Patient Information
Template Patient Information Form (PIF) (English, Dutch, Portuguese or Italian):


Template Opt-Out for patients (English, Dutch, Portuguese or Italian):


CAPACITY one pager (English only):

Please contact us for the Data Transfer Agreement (DTA).

UK Study Protocol



UK Data Dictionary


UK Capacity Frequently Asked Questions


Admiraal de Ruyter HospitalGoesThe Netherlands
Albert Schweitzer HospitalDordrechtThe Netherlands
Amphia HospitalBredaThe Netherlands
Amstelland HospitalAmstelveenThe Netherlands
Amsterdam University Medical CenterAmsterdamThe Netherlands
Antonius HospitalSneekThe Netherlands
Antwerp University HospitalAntwerpenBelgium
AZ Maria MiddelaresGentBelgium
Barts Health NHS TrustLondonUnited Kingdom
Beatrix HospitalGorinchemThe Netherlands
Bernhoven HospitalUdenThe Netherlands
Bravis HospitalRoosendaalThe Netherlands
Catharina HospitalEindhovenThe Netherlands
CHU UCL Namur – Site GodinneYvoirBelgium
Deventer HospitalDeventerThe Netherlands
DiakonessenhuisUtrechtThe Netherlands
Dijklander HospitalPurmerend – HoornThe Netherlands
Elizabeth-TweeSteden Hospital TilburgThe Netherlands
EMMS HospitalNazarethIsrael
Erasmus University Medical CenterRotterdamThe Netherlands
Fransiscus GasthuisRotterdamThe Netherlands
Fransiscus VlietlandRotterdamThe Netherlands
Gelre HospitalsApeldoornThe Netherlands
Gelre HospitalsZuthpenThe Netherlands
Groene Hart HospitalGoudaThe Netherlands
Haaglanden Medical Centerden HaagThe Netherlands
Hospital do Espirito SantoÉvoraPortugal
Hospital Group TwenteAlmeloThe Netherlands
Hospital Prof. Doutor Fernando FonescaAmadoraPortugal
Hospital Universitario Virgen de las NievesGranadaSpain
I.M. Sechenov First Moscow State Medical UniversityMoscowRussia
Ikazia HospitalRotterdamThe Netherlands
Imperial College Healthcare NHS TrustLondonUnited Kingdom
Incliva Research Institute, University of ValenciaValenciaSpain
IsalaZwolleThe Netherlands
Jeroen Bosch Hospital‘s-HertogenboschThe Netherlands
Jessa HospitalHasseltBelgium
King Fahd Hospital of the UniversityKhobarSaudi Arabia
LangeLand HospitalZoetermeerThe Netherlands
Leeds Teaching Hospitals NHS TrustLeedsUnited Kingdom
Leeuwarden Medical CenterLeeuwardenThe Netherlands
Leiden University Medical CenterLeidenThe Netherlands
Maasstad HospitalRotterdamThe Netherlands
Maastricht University Medical CenterMaastrichtThe Netherlands
Manchester University NHS Foundation TrustManchesterUnited Kingdom
Martini HospitalGroningenThe Netherlands
Meander Medical CenterAmersfoortThe Netherlands
Medisch Spectrum TwenteEnschedeThe Netherlands
Northumbria Healthcare NHS Foundation TrustNewcastleUnited Kingdom
One Day Surgery HospitalCairoEgypt
Queen Elizabeth University HospitalGlasgowUnited Kingdom
Rijnstate HospitalArnhemThe Netherlands
Rode Kruis HospitalBeverwijkThe Netherlands
Royal Brompton and Harefield NHS Foundation TrustLondonUnited Kingdom
Royal Devon and Exeter NHS Foundation TrustExeterUnited Kingdom
Royal Free London NHS Foundation TrustLondonUnited Kingdom
Salford Royal NHS Foundation TrustSalfordUnited Kingdom
San Luigi Gonzaga University HospitalOrbassanoItaly
Saxenburgh Medical CenterHardenbergThe Netherlands
Slingeland HospitalDoetinchemThe Netherlands
Southern Health and Social Care TrustPortadownUnited Kingdom
Spaarne GasthuisHaarlemThe Netherlands
SSR Val RosaySaint-Didier-au-Mont-d’OrFrance
St. Antonius HospitalNieuwegeinThe Netherlands
St. JansdalHarderwijkThe Netherlands
Tehran Heart CenterTehranIran
The Newcastle upon Tyne Hospitals NHS Foundation Trust NewcastleUnited Kingdom
Treant ZorggroepHoogeveenThe Netherlands
University College London Hospitals NHS Foundation TrustLondonUnited Kingdom
University Hospital BrusselsBrusselsBelgium
University Hospital Complex of GranadaGranadaSpain
University Hospital of GenevaGenevaSwitzerland
University Hospitals Bristol NHS Foundation TrustBristolUnited Kingdom
University Hospitals of Leicester NHS TrustLeicesterUnited Kingdom
University Medical Center Utrecht AntwerpBelgium
van Weel-Bethseda HospitalDirkslandThe Netherlands
Zaans Medical CenterZaandamThe Netherlands
Zuyderland Medical CenterHeerlenThe Netherlands

Together we are investigating the role cardiovascular disease in the COVID-19 pandemic. We sincerely invite our international colleagues and researchers to apply for data access or to join efforts that are already ongoing. The following six research questions have formulated by the Data Access Committee and are being assessed: 

  1. What is the incidence and pattern of cardiovascular complications in patients with COVID-19?
  2. Does the clinical presentation of COVID-19 differ between patients with and without a history of cardiovascular disease?
  3. What is the extent of cardiac damage in patients with COVID-19?
  4. Do patients with COVID-19 and cardiovascular risk factors or underlying cardiovascular disease have a worse disease course? If this is the case, which cardiovascular risk factors and types of cardiovascular diseases are especially associated with a poor outcome?
  5. Does the use of medication that influence ACE-2 expression worsen the course of COVID-19 (ACEi, ARBs, NSAIDs and thiazolidinediones)?
  6. What is the effect of therapy for COVID-19 on patients with cardiac complications or underlying cardiovascular disease? E.g. chloroquine and effect on QT-interval.

The following requests for data access have been approved:
  1. Oral anticoagulation and COVID-19 outcome – Disease modifiers 
  2. Sex differences in COVID-19 
  3. Effect of diabetes on COVID-19 cardiovascular complications
  4. Acute cardiac injury and ACS in COVID-19 
  5. Arrhythmias and conduction disorders in COVID-19
  6. Non-invasive 12-lead ECG analysis in patients with COVID-19 
  7. Disease-specific ECG features in patients with COVID-19

Contact us to join already ongoing projects

How to apply for data access:

  • First check the overview of applications to avoid overlap with an existing project.
  • Start your application by filling in the application form via By sending this form the request will go to
  • To gain access, this form including your research questions, required data and/or samples, financing, and timeline of the research must be submitted
  • Make your data selection using this specific CAPACITY REDCap codebook. Please select your variables with corresponding variable names and labels. This file must be submitted as well alongside the application form using
  • The submitted application will be reviewed within one week by the CAPACITY Data Access Committee.
  • Once an application is approved, CAPACITY will prepare a Data Transfer Agreement (DTA) for you to sign.
  • Data will be released after signing the DTA.
  • The data will be released in a digital research environment (the CAPACITY workspace). 
  • For further information regarding data access see this file.


For more information, click on the questions below or contact us.

All patients who have tested positive or are highly suspected of COVID-19 and are admitted to the hospital. Patients who do not opt-out can be included in the registry.

This research is observational, data acquired during routine clinical care will be registered. Data of the admission will be collected with standardized Data Collection Instruments in REDCap. In addition to the ISARIC-WHO CRF, the CAPACITY REDCap project has multiple additional Data Collection Instruments, including: cardiac history and cardiovascular risk factors, cardiac biomarkers, ECG, echocardiography, cardiac MRI, invasive cardiac procedures, cardiac complications during admission and cardiac outcome after 7 and 30 days.

Data will be stored secured and de-identified by using a unique study code in a REDCap registry.